NeutroCure-ROS-amplifiers target neutrophils (see below the representative images of bone marrow (BM) niche and neutrophils in the BM: courtesy of A. Hidalgo Alonso and I. Cossío Cuartero, CNIC, Spain).
Potential beneficiary therapeutic effects of ROS amplifiers
- ROS-induced inhibition of PMN-myeloid derived suppressor cells can inhibit cancer growth,
- ROS-induced deactivation of T-cells and neutrophil extracellular traps (NETs) generation contributes to resolution of inflammation,
- ROS-induced boosting of haematopoiesis can relieve myeloablation.