Funding Programme: FETOPEN-01-2018-2019-2020 – FET-Open Challenging Current Thinking. The project is running from 01.01.2020 until 31.12.2024.
Concept
NeutroCure – Methodology
Specific microenvironment is established under disease conditions: for example, elevated levels of ROS are present in cancer cells and tumors as well as in aberrant polymorphonuclear neutrophils (PMN’s) in infammatory and autoimmune diseases.
Nuclei staining: DAPI. ROS staining: MitoSOXNeutroCure will make use of these differences between pathological and normal states to develop safe ROS-amplifiers targeting aberrant PMN’s. These amplifiers can be potentially used for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.